Sunday March 4, 2007
Vancomycin dosing in CRRT

Vancomycin dosing is different in CRRT (Continuous Renal Replacement Therapy) from IHD (Intermittent HemoDialysis) as vancomycin is effectively removed during CRRT. Vancomycin is 14K daltons and CRRT filter removes upto 20K daltons size molecules. Frequent monitoring of Vancomycin level is required. Different intervals has been described from 24 to 48 hours. Most agree on 10 mg/kg every 24 hours. Ultimate goal is to keep vancomycin trough atleast between 10 - 15 mcg/ml.

Related: ppt slides on CRRT from Gregory M. Susla Pharm.D here .


References: Click to get abstract/article

1. Vancomycin dosing and monitoring - Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center (CUMC), columbia.edu
2. CVVH Initial Drug Dosing Guidelines - from thedrugmonitor.com